Mice with human immune system components as in vivo models for infections with human pathogens
Identifieur interne : 000C39 ( Main/Exploration ); précédent : 000C38; suivant : 000C40Mice with human immune system components as in vivo models for infections with human pathogens
Auteurs : Patrick C. R Mer ; Obinna Chijioke ; Sonja Meixlsperger ; Carol S. Leung ; Christian MünzSource :
- Immunology and cell biology [ 0818-9641 ] ; 2011.
Abstract
Many pathogens relevant to human disease do not infect other animal species. Therefore, animal models that reconstitute or harbour human tissues are explored as hosts for these. In this review, we will summarize recent advances to utilize mice with human immune system components, reconstituted from hematopoietic progenitor cells in vivo. Such mice can be used to study human pathogens that replicate in leucocytes. In addition to studying the replication of these pathogens, the reconstituted human immune system components can also be analyzed for initiating immune responses and control against these infections. Moreover, these new animal models of human infectious disease should replicate the reactivity of the human immune system to vaccine candidates and, especially, the adjuvants contained in them, more faithfully.
Url:
DOI: 10.1038/icb.2010.151
PubMed: 21301484
PubMed Central: 3087174
Affiliations:
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